6 . 867 Machine learning : lecture 3

The results from the small scale application are encouraging. Our model successfully reproduces known behavior of the λ−switch on the basis of molecular level competition and resource constraints, without the need to assume protein-protein interactions between cI2 dimers and cI2 and RNA-polymerase. Even in the context of this well-known sub-system, however, few quantitative experimental results are available about binding. Proper validation and use of our model therefore relies on estimating the game parameters from available protein-DNA binding data (in progress). Once the game parameters are known, the model provides valid predictions for a number of possible perturbations to the system, including changing nuclear concentrations and knock-outs. Acknowledgments